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Light-addressable Potentiometric Sensor (LAPS) Combined with Multi-chamber Structures to Investigate the Metabolic Activity of Cells.

Authors :
Dantism, S.
Takenaga, S.
Wagner, P.
Wagner, T.
Schöning, M.J.
Source :
Procedia Engineering; 2015, p384-387, 4p
Publication Year :
2015

Abstract

LAPS are field-effect-based potentiometric sensors which are able to monitor analyte concentrations in a spatially resolved manner. Hence, a LAPS sensor system is a powerful device to record chemical imaging of the concentration of chemical species in an aqueous solution, chemical reactions, or the growth of cell colonies on the sensor surface, to record chemical images. In this work, multi-chamber 3D-printed structures made out of polymer (PP-ABS) were combined with LAPS chips to analyse differentially and simultaneously the metabolic activity of Escherichia coli K12 and Chinese hamster ovary (CHO) cells, and the responds of those cells to the addition of glucose solution. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
18777058
Database :
Supplemental Index
Journal :
Procedia Engineering
Publication Type :
Academic Journal
Accession number :
112054664
Full Text :
https://doi.org/10.1016/j.proeng.2015.08.647