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Pharmacological effects of ethanol extract of Egyptian Artemisia herba-alba in rats and mice.
- Source :
- Asian Pacific Journal of Tropical Biomedicine; Jan2016, Vol. 6 Issue 1, p44-49, 6p
- Publication Year :
- 2016
-
Abstract
- Objective To investigate some pharmacological effects including gastroprotective, anti-inflammatory, analgesic, antipyretic and in vitro antioxidant effects of Artemisia herba-alba extract in different experimental models. Methods Inflammation was induced in rat paw by subcutaneous injection of 1% (v/v) carrageenan solution. Writhes was induced in mice by intraperitoneal injection of 0.6% (v/v) acetic acid solution. Pyrexia was induced using Brewer's yeast suspension. Gastric lesion was induced in rats by oral administration of 99% ethanol. The anti-inflammatory, analgesic, antipyretic and gastroprotective activities of Artemisia herba-alba extract were investigated respectively. In vitro antioxidant effect was investigated using DPPH free radical. Results The plant extract showed anti-inflammatory effect in carrageenan-induced paw edema in rats, analgesic effect against acetic acid-induced writhing, and antipyretic activity in Brewer's yeast model of pyrexia. Besides, it was shown to be a gastroprotective agent against ethanol-induced gastric ulcers. The plant also exhibited a free radical scavenging potential in an in vitro antioxidant study using DPPH. Conclusions The results validate the use of the investigated plant in traditional medicine for different ailments. [ABSTRACT FROM AUTHOR]
- Subjects :
- ARTEMISIA
DRUG efficacy
ANTI-infective agents
IN vitro studies
ANTIOXIDANTS
Subjects
Details
- Language :
- English
- ISSN :
- 22211691
- Volume :
- 6
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Asian Pacific Journal of Tropical Biomedicine
- Publication Type :
- Academic Journal
- Accession number :
- 111893103
- Full Text :
- https://doi.org/10.1016/j.apjtb.2015.10.005