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p38α controls self-renewal and fate decision of neurosphere-forming cells in adult hippocampus.
- Source :
- FEBS Open Bio; 2015, Vol. 5, p437-444, 8p
- Publication Year :
- 2015
-
Abstract
- Neural stem cells (NSC) from the adult hippocampus easily lose their activity in vitro . Efficient in vitro expansion of adult hippocampus-derived NSC is important for generation of tools for research and cell therapy. Here, we show that a single copy disruption or pharmacological inhibition of p38α enables successful long-term neurosphere culture of adult mouse hippocampal cells. Expanded neurospheres with high proliferative activity differentiated into the three neuronal lineages under differentiating conditions. Thus, inhibition of p38α can maintain adult hippocampal NSC activity in vitro . [ABSTRACT FROM AUTHOR]
- Subjects :
- HIPPOCAMPUS (Brain)
NEUROGLIA
NEURAL stem cells
DENTATE gyrus
IN vitro studies
Subjects
Details
- Language :
- English
- ISSN :
- 22115463
- Volume :
- 5
- Database :
- Supplemental Index
- Journal :
- FEBS Open Bio
- Publication Type :
- Academic Journal
- Accession number :
- 111566180
- Full Text :
- https://doi.org/10.1016/j.fob.2015.05.001