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Expression of serum amyloid A4 in human trophoblast-like choriocarcinoma cell lines and human first trimester/term trophoblast cells.
- Source :
- Placenta; 2014 Aug, Vol. 35 Issue 8, p661-664, 4p
- Publication Year :
- 2014
-
Abstract
- Trophoblast invasion into uterine tissues represents a hallmark of first trimester placental development. As expression of serum amyloid A4 (SAA4) occurs in tumorigenic and invasive tissues we here investigated whether SAA4 is present in trophoblast-like human AC1-M59/Jeg-3 cells and trophoblast preparations of human first trimester and term placenta. SAA4 mRNA was expressed in non-stimulated and cytokine-treated AC1-M59/Jeg-3 cells. In purified trophoblast cells SAA4 mRNA expression was upregulated at weeks 10 and 12 of pregnancy. Western-blot and immunohistochemical staining of first trimester placental tissue revealed pronounced SAA4 expression in invasive trophoblast cells indicating a potential role of SAA4 during invasion. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01434004
- Volume :
- 35
- Issue :
- 8
- Database :
- Supplemental Index
- Journal :
- Placenta
- Publication Type :
- Academic Journal
- Accession number :
- 107798194
- Full Text :
- https://doi.org/10.1016/j.placenta.2014.05.012