Hypoallergenic cupcake is a useful product for wheat-sensitive allergic patients.

Background: We tried to clarify the safety and usefulness of a hypoallergenic cupcake in 9 patients with atopic dermatitis, who had wheat allergy. All patients had a history of severe urticaria, when cereal-based products were ingested.Method: We determined CAP-RAST for wheat as well as ELISA for wheat, the hypoallergenic wheat, and the salt-soluble and salt-insoluble fractions of wheat.Result: Positive correlations were observed between CAP-RAST and ELISA of wheat (P<0.015), between ELISA of wheat and the hypoallergenic wheat (P<0.043). There was a positive correlation between ELISA of the salt-soluble and salt-insoluble fractions (P<0.005). The provocation with the hypoallergenic cupcake showed a positive immediate reaction (severe urticaria) in only 2 patients. ELISA of hypoallergenic wheat of these 2 patients showed a high titer of more than 0.1.Conclusion: The hypoallergenic cupcake is safe in most patients with wheat allergy, if ELISA of the hypoallergenic wheat is examined before ingestion. [ABSTRACT FROM AUTHOR]