Improved Stool DNA Integrity Method for Early Colorectal Cancer Diagnosis.

Authors :: Rengucci, Claudia
De Maio, Giulia
Menghi, Maura
Scarpi, Emanuela
Guglielmo, Simona
Fusaroli, Pietro
Caletti, Giancarlo
Saragoni, Luca
Gardini, Andrea Casadei
Zoli, Wainer
Falcini, Fabio
Amadori, Dino
Calistri, Daniele
Source :: Cancer Epidemiology, Biomarkers & Prevention; Nov2014, Vol. 23 Issue 11, p2553-2560, 8p
Publication Year :: 2014
Abstract: The article presents research that aims to improve accuracy of early detecting colorectal cancer through stool DNA integrity analysis. It informs that DNA from stool was extracted from 241 samples using manual and semiautomatic extraction systems and DNA was further analyzed using fluorescence long DNA (FL-DNA) tests by capillary electrophoresis (CE) and real time (RT) assays. It informs that RT FL-DNA analysis improved the quality of DNA from stool samples.