New bioactive derivatives of nonactic acid from the marine Streptomyces griseus derived from the plant Salicornia sp.

Three new compounds, butyl homononactate ( 5 ), butyl nonactate ( 6 ), 8-actyl homononactic acid ( 7 ), along with four known compounds homononactic acids ( 1 ), nonactic acid ( 2 ), homononactyl nonactate ( 3 ), homononactyl homononactate ( 4 ) were isolated from the marine Streptomyces griseus RSH0407, derived from the plant Salicornia sp., Chenopodiaceae. Their structures were elucidated by extensive spectroscopic techniques and by comparison with data reported in the literature. The absolute configuration of 3 was first reported by using X-ray copper radiation. Compound 5 exhibited cytotoxic activities against the HCT-8, A2780, BGC-823, BEL-7402, and A549 cell lines in vitro , with IC 50 values of 2.87 ± 0.20, 4.90 ± 0.30, 2.19 ± 0.32, 5.07 ± 0.23 and 1.78 ± 0.18 μM, respectively, and compounds 4 – 7 showed weak antibacterial activities against four bacterials respectively. [ABSTRACT FROM AUTHOR]