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Meta-Analysis of Association Between Interleukin-1β C-511T Polymorphism and Chronic Periodontitis Susceptibility.
- Source :
- Journal of Periodontology; Jun2015, Vol. 86 Issue 6, p812-819, 8p
- Publication Year :
- 2015
-
Abstract
- Background: Many studies have been conducted to explore the association between interleukin (IL)-1β C-511T polymorphism and risk of chronic periodontitis (CP) but with different or even contradictory results. A meta-analysis was performed to further explore their association. Methods: PubMed, Chinese Mational Knowledge Infrastructure, and EMBASE were searched up to September 30, 2014 for relevant case-control studies. Two authors (DYL and L-YX) independently selected studies and extracted data from included studies. The meta-analysis was performed using comprehensive meta-analysis software. Results: Nineteen case-control studies involving 2,173 patients with CP and 3,900 healthy controls were included. Using a random-effects meta-analysis model, a non-significant association between IL-1β C-51 IT polymorphism and CP was identified (T versus C: odds ratio [OR] = 1.03, 95% confidence interval [Cl] = 0.85 to 1.25; TT versus CC: OR = 1.03, 95% Cl = 0.72 to 1.46; CT versus CC: OR = 0.96, 95% Cl = 0.71 to 1.30; CT + TT versus CC: OR = 1.00, 95% Cl = 0.74 to 1.34; TT versus CT + CC: OR = 1.05, 95% Cl = 0.81 to 1.38), and sensitivity analysis indicated that the results were robust. Subgroup analyses also revealed a non-significant association. No publication bias was detected. Conclusions: Based on currently available evidence, IL-1β C-51 IT polymorphism is not associated with the risk of developing CP. Additional research is warranted to further explore and confirm the association of genetic polymorphism and CP. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00223492
- Volume :
- 86
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Journal of Periodontology
- Publication Type :
- Academic Journal
- Accession number :
- 103197440
- Full Text :
- https://doi.org/10.1902/jop.2015.140698