Back to Search
Start Over
HS–4, a highly potent inhibitor of cell proliferation of human cancer cell.
- Source :
- Asian Pacific Journal of Tropical Medicine; May2015, Vol. 8 Issue 5, p417-420, 4p
- Publication Year :
- 2015
-
Abstract
- Objective To investigate the antitumor activity of the compound HS-4 and the action mechanism. Methods MTT method was used to test in vitro antitumor activity of the compound HS-4. Orthotopic xenotransplantation tumor model of liver cancer was established in nude mice, and, in vivo antitumor activity of compound HS-4 was tested with a small animal in-vivo imaging system. Sequencing of small RNA library and RNA library was performed in HS-4 treated tumor cell group and control group to investigate the anti-cancer mechanism of HS-4 at level of functional genomics, using high-throughput sequencing technology. Results HS-4 was found to have relatively high in-vitro antitumor activity against liver cancer cells, gastric cancer cells, renal cancer cells, lung cancer cells, breast cancer cells and colon cancer cells. The IC 50 values against SMMC-7721 and Bel-7402 of liver cancer cells were 0.14 and 0.13 nmol/L respectively, while the IC 50 values against MGC-803 and SGC-7901 of gastric cancer cells were 0.19 and 0.21 nmol/L, respectively. It was demonstrated that HS-4 possessed a better therapeutic effect in liver cancer. Conclusions A new reliable orthotopic xenotransplantation tumor model of liver cancer in nude mice is established. The new compounds HS-4 was found to possess relatively high in vivo and in vitro antitumor activity against liver cancer cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19957645
- Volume :
- 8
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- Asian Pacific Journal of Tropical Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 102786176
- Full Text :
- https://doi.org/10.1016/S1995-7645(14)60354-0