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GATA-Binding Factor 6 Contributes to Atrioventricular Node Development and Function.
- Source :
- Circulation: Cardiovascular Genetics; Apr2015, Vol. 8 Issue 2, p284-293, 10p
- Publication Year :
- 2015
-
Abstract
- The article discusses a research which examines the role of GATA-binding factor 6 (GATA6) in cardiac conduction system (CCS) and embryonic heart. It indicates that myocardial-specific deletion of the carboxyl zinc-finger of Gata6 alters the CCS in postnatal life and reduces cell-cycle exit of TBX3+ myocytes in the developing atrioventricular bundle. It reveals that GATA6 contributes to the atrioventricular node's development and postnatal function.
Details
- Language :
- English
- ISSN :
- 1942325X
- Volume :
- 8
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Circulation: Cardiovascular Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 102623224
- Full Text :
- https://doi.org/10.1161/CIRCGENETICS.113.000587