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Synthesis and antimicrobial activity of α-aminophosphonates containing chitosan moiety.
- Source :
- Arabian Journal of Chemistry; May2015, Vol. 8 Issue 3, p427-432, 6p
- Publication Year :
- 2015
-
Abstract
- A novel series of α-aminophosphonates containing chitosan moiety was obtained in high yields from reactions of chitosan with aromatic aldehydes and triphenylphosphite in the presence of lithium perchlorate as a catalyst. The structures of the synthesized compounds were confirmed by IR and 1 H NMR spectral data. Compounds ( 1 – 4 ) showed high antimicrobial activities against Escherichia coli (NCIM2065), Serratia marcescens , Enterobacter cloacae , Shigella dysenteriae , Salmonella enterica and Proteus vulgaris as Gram-negative bacteria, Bacillus subtilis (PC1219) and Staphylococcus aureus (ATCC25292) as Gram-positive bacteria and Candida albicans as a fungus, at low concentrations (2.5–10 mg/mL). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 18785352
- Volume :
- 8
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Arabian Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 102189634
- Full Text :
- https://doi.org/10.1016/j.arabjc.2013.12.029