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Lidocaine increases the anti-inflammatory cytokine IL-10 following mechanical ventilation in healthy mice.
- Source :
- Acta Anaesthesiologica Scandinavica; Jan2015, Vol. 59 Issue 1, p47-55, 9p, 5 Graphs
- Publication Year :
- 2015
-
Abstract
- Background Mechanical ventilation ( MV) induces an inflammatory response that may result in (acute) lung injury. Lidocaine, an amide local anesthetic, has anti-inflammatory properties in vitro and in vivo, possibly due to an attenuation of pro-inflammatory cytokines, intracellular adhesion molecule-1 ( ICAM-1), and reduction of neutrophils influx. We hypothesized an attenuation of MV-induced inflammatory response with intravenously administered lidocaine. Methods Lidocaine ( Lido) (2, 4, and 8 mg/kg/h) was intravenously administered during 4 h of MV with a tidal volume of 8 ml/kg, positive end expiratory pressure 1,5 cmH<subscript>2</subscript>O and FiO<subscript>2</subscript> 0.4. We used one ventilated control ( CON) group receiving vehicle. After MV, mice were euthanized, and lungs and blood were immediately harvested, and cytokine levels and ICAM-1 levels were measured in plasma and lung homogenates. Pulmonary neutrophils influx was determined in LEDER-stained slices of lungs. Anesthetic need was determined by painful hind paw stimulation. Results Lidocaine-treated animals ( Lido 2, 4 and 8 mg/kg/h) showed higher interleukin ( IL)-10 plasma levels compared to control animals. Lidocaine treatment with 8 mg/kg/h ( Lido 8) resulted in higher IL-10 in lung homogenates. No differences were observed in pro-inflammatory cytokines, ICAM-1, and pulmonary influx between the different ventilated groups. Conclusions Intravenously administered lidocaine increases levels of plasma IL-10 with infusion from 2, 4, and 8 mg/kg/h and pulmonary levels of IL-10 with 8 mg/kg/h in a murine mechanical ventilation model. Intravenously administered lidocaine appears to reduce anesthetic need in mice. [ABSTRACT FROM AUTHOR]
- Subjects :
- LIDOCAINE
LABORATORY mice
CYTOKINES
AMIDES
MYOCARDIAL depressants
Subjects
Details
- Language :
- English
- ISSN :
- 00015172
- Volume :
- 59
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Acta Anaesthesiologica Scandinavica
- Publication Type :
- Academic Journal
- Accession number :
- 99885486
- Full Text :
- https://doi.org/10.1111/aas.12417