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Elevation of Peripheral BDNF Promoter Methylation Links to the Risk of Alzheimer's Disease.

Elevation of Peripheral BDNF Promoter Methylation Links to the Risk of Alzheimer's Disease.

Authors :
Chang, Lan
Wang, Yunliang
Ji, Huihui
Dai, Dongjun
Xu, Xuting
Jiang, Danjie
Hong, Qingxiao
Ye, Huadan
Zhang, Xiaonan
Zhou, Xiaohui
Liu, Yu
Li, Jinfeng
Chen, Zhongming
Li, Ying
Zhou, Dongsheng
Zhuo, Renjie
Zhang, Yuzheng
Yin, Honglei
Mao, Congcong
Duan, Shiwei
Source :
PLoS ONE; Nov2014, Vol. 9 Issue 11, p1-7, 7p
Publication Year :
2014

Abstract

Brain derived neurotrophic factor (BDNF) has been known to play an important role in various mental disorders or diseases such as Alzheimer's disease (AD). The aim of our study was to assess whether BDNF promoter methylation in peripheral blood was able to predict the risk of AD. A total of 44 AD patients and 62 age- and gender-matched controls were recruited in the current case-control study. Using the bisulphite pyrosequencing technology, we evaluated four CpG sites in the promoter of the BDNF. Our results showed that BDNF methylation was significantly higher in AD cases than in the controls (CpG1: p = 10.021; CpG2: p = 0.002; CpG3: p = 0.007; CpG4: p = 0.005; average methylation: p = 0.004). In addition, BDNF promoter methylation was shown to be significantly correlated with the levels of alkaline phosphatase (ALP), glucose, Lp(a), ApoE and ApoA in males (ALP: r = −0.308, p = 0.042; glucose: r = −0.383, p = 0.010; Lp(a): r = 0.333, p = 0.027; ApoE: r = −0.345, p = 0.032;), ApoA levels in females (r = 0.362, p = 0.033), and C Reactive Protein (CRP) levels in both genders (males: r = −0.373, p = 0.016; females: r = −0.399, p = 0.021). Our work suggested that peripheral BDNF promoter methylation might be a diagnostic marker of AD risk, although its underlying function remains to be elaborated in the future. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
19326203
Volume :
9
Issue :
11
Database :
Complementary Index
Journal :
PLoS ONE
Publication Type :
Academic Journal
Accession number :
99732267
Full Text :
https://doi.org/10.1371/journal.pone.0110773