Synthesis of Some New Benzimidazole-Thiazole Derivatives as Anticancer Agents.

4-(1 H-benzo[d]imidazol-2-yl)thiazol-2-amine and its 1-methyl derivative ( 1) were reacted with different reagents such as acid anhydrides, malononitrile, chloroacetyl chloride, and aromatic aldehydes to produce the corresponding benzimidazole products 2, 3, 4, 5, 6, 7, 8, 9, respectively. Also, 2-chloro- N-(4-(1-methyl-1 H-benzo[d]imidazol-2-yl)thiazol-2-yl) acetamide ( 6) was reacted with diaminoethane, ortho-substituted aniline, thioglycolic acid, thiosemicarbazide derivatives, secondary amines, and potassium isothiocyanate to afford the corresponding derivatives 10, 11, 12, 13, 14, 15, 16, 17, respectively. The cytotoxic activity of some newly synthesized derivatives was studied against two different cell lines HepG2 and PC12. Compounds 9 and 15b showed promising anticancer activity against both types of the tested cancerous cell lines. [ABSTRACT FROM AUTHOR]