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Re-irradiation in head and neck cancers: an Indian tertiary cancer centre experience.
- Source :
- Journal of Laryngology & Otology; Nov2014, Vol. 128 Issue 11, p996-1002, 7p
- Publication Year :
- 2014
-
Abstract
- Objective:To explore the treatment outcomes of patients treated with re-irradiation for recurrent or second primary head and neck cancer.Method:An analysis was performed of 79 head and neck cancer patients who underwent re-irradiation for second primaries or recurrent disease from January 1999 to December 2011.Results:Median time from previous radiation to re-irradiation for second primary or recurrence was 53.6 months (range, 2.7–454.7 months). Median age at diagnosis of first primary was 54 years. Median re-irradiation dose was 45 Gy (range, 45–60 Gy). Acute grade 3 or worse toxicity was seen in 30 per cent of patients. Median progression-free survival for recurrent disease was 15.0 months (95 per cent confidence interval, 8.33–21.66). The following factors had a statistically significant, positive impact on progression-free survival: patient age of less than 50 years (median progression-free survival was 29.43, vs 13.9 months for those aged 50 years or older; p = 0.004) and disease-free interval of 2 years or more (median progression-free survival was 51.66, vs 13.9 months for those with less than 2 years disease-free interval).Conclusion:Re-irradiation of second primaries or recurrences of head and neck cancers with moderate radiation doses yields acceptable progression-free survival and morbidity rates. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 00222151
- Volume :
- 128
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Journal of Laryngology & Otology
- Publication Type :
- Academic Journal
- Accession number :
- 99467617
- Full Text :
- https://doi.org/10.1017/S0022215114002497