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Bioinformatics in otolaryngology research. Part two: other high-throughput platforms in genomics and epigenetics.
- Source :
- Journal of Laryngology & Otology; Nov2014, Vol. 128 Issue 11, p942-947, 6p
- Publication Year :
- 2014
-
Abstract
- Objectives:This second segment of the two-part review summarises several modern high-throughput methods in genomics, epigenetics and molecular biology. Many principles from nucleotide sequencing and transcriptomics can be applied to other high-throughput molecular biology techniques. Specifically, this manuscript reviews: array comparative genome hybridisation; single nucleotide polymorphism arrays; microarray technology, used to study epigenetics; and methodology applied in proteomics. Finally, the review describes current methods for the integration of multiple molecular biology platforms.Conclusion:Progress in treating human disease in general will require close collaboration with experts in bioinformatics. Improved understanding, by clinicians and physician-scientists in our field, of the concepts presented in both parts of this review will advance diagnosis and therapy for diseases of the head and neck. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 00222151
- Volume :
- 128
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Journal of Laryngology & Otology
- Publication Type :
- Academic Journal
- Accession number :
- 99467603
- Full Text :
- https://doi.org/10.1017/S0022215114002011