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Quantification of dynamic changes to blood volume and vascular flow in the primate corpus luteum during the menstrual cycle.
- Source :
- Journal of Medical Primatology; Dec2014, Vol. 43 Issue 6, p445-454, 10p
- Publication Year :
- 2014
-
Abstract
- Background The objective of the current study was to determine changes to vascular parameters of nonhuman primate dominant ovarian structures by dynamic contrast-enhanced ultrasound ( DCE- US). Materials and Methods Dynamic contrast-enhanced ultrasound with intravenous microbubble infusion was performed on the rhesus macaque ovary bearing the pre-ovulatory follicle and corpus luteum ( CL) sequentially during the natural luteal phase (n = 8) and Gn RH antagonist (antide)-induced luteal regression (n = 6). Results Changes in luteal blood volume ( BV) and vascular flow ( VF) were observed between stages of the luteal phase Luteal BV was highest in early stage CL, before decreasing 2.5-fold in late stage CL ( P < 0.06); in contrast, luteal VF peaked at mid luteal stage ( P < 0.01). Two females identified with luteal insufficiency trended toward lower peak BV, compared to typical CLs. Another female was identified with a luteal cyst on the contralateral ovary, and a CL that regressed before P levels declined. After 72 hours of antide exposure, BV was reduced 2.3-fold ( P = 0.03). Conclusions DCE-US provides a sensitive, non-invasive measurement of the dynamics of blood volume and flow in dominant ovarian structures. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00472565
- Volume :
- 43
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Journal of Medical Primatology
- Publication Type :
- Academic Journal
- Accession number :
- 99412521
- Full Text :
- https://doi.org/10.1111/jmp.12132