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Prognostic significance of YWHAZ expression in localized prostate cancer.
- Source :
- Prostate Cancer & Prostatic Diseases; Dec2014, Vol. 17 Issue 4, p310-314, 5p
- Publication Year :
- 2014
-
Abstract
- Background:Prostate cancer (PCa) patients are often over-treated because of the lack of biomarkers needed to distinguish the lethal from the indolent form of PCa. YWHAZ was recently identified as a potential therapeutic target in castration-resistant PCa (CRPC). Therefore, this study focused on determining the prognostic significance of YWHAZ in localized PCa.Methods:YWHAZ expression was assessed by immunohistochemistry on formalin-fixed paraffin-embedded tissue from 213 men who underwent radical prostatectomy. Kaplan-Meier analysis and Cox proportional-hazards models were used to assess the prognostic value of YWHAZ intensity.Results:High YWHAZ expression was strongly associated with high Gleason score at the time of diagnosis (P<0.001) and PSA relapse (P=0.001). Importantly, patients with high expression of YWHAZ had a higher risk of CRPC development (P=0.002) and reduced survival time (P=0.002).Conclusions:Our findings indicate that YWHAZ could serve as a promising prognostic biomarker in localized PCa to predict poor prognosis and to identify a subgroup of tumors, which might benefit from earlier adjuvant or YWHAZ-targeted therapy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13657852
- Volume :
- 17
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Prostate Cancer & Prostatic Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 99315415
- Full Text :
- https://doi.org/10.1038/pcan.2014.32