Melanoma Cells Break Down LPA to Establish Local Gradients That Drive Chemotactic Dispersal.

Authors :: Muinonen-Martin, Andrew J.
Susanto, Olivia
Zhang, Qifeng
Smethurst, Elizabeth
Faller, William J.
Veltman, Douwe M.
Kalna, Gabriela
Lindsay, Colin
Bennett, Dorothy C.
Sansom, Owen J.
Herd, Robert
Jones, Robert
Machesky, Laura M.
Wakelam, Michael J. O.
Knecht, David A.
Insall, Robert H.
Source :: PLoS Biology; Oct2014, Vol. 12 Issue 10, p1-17, 17p, 1 Color Photograph, 1 Diagram, 7 Graphs
Publication Year :: 2014
Abstract: : Melanoma cells break down lysophosphatidic acid from the environment, creating a chemotactic gradient that the tumor cells then follow; this provides an explanation for the rapid metastasis of melanoma. [ABSTRACT FROM AUTHOR]

Subjects :: MELANOMA
CANCER cells
CHEMOTACTIC factors
TUMORS
LYSOPHOSPHOLIPIDS
LYSOPHOSPHATIDIC acid receptors

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