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Positive patch test reactions to oxidized limonene: exposure and relevance.
- Source :
- Contact Dermatitis (01051873); Nov2014, Vol. 71 Issue 5, p264-272, 9p
- Publication Year :
- 2014
-
Abstract
- Background R-Limonene is a common fragrance terpene found in domestic and industrial products. R- Limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. In a recent multicentre study, 5.2% (range 2.3-12.1%) of 2900 patients showed a positive patch test reaction to oxidized R-limonene. Objective To study the exposure to limonene among consecutive dermatitis patients reacting to oxidized R-limonene in an international setting, and to assess the relevance of the exposure for the patients' dermatitis. Methods Oxidized R-limonene 3.0% (containing limonene hydroperoxides at 0.33%) in petrolatum was tested in 2900 consecutive dermatitis patients in Australia, Denmark, the United Kingdom, Singapore, Spain, and Sweden. A questionnaire assessing exposure to limonene-containing products was completed. Results Overall, exposure to products containing limonene was found and assessed as being probably relevant for the patients' dermatitis in 36% of the limonene-allergic patients. In Barcelona and Copenhagen, > 70% of the patients were judged to have had an exposure to limonene assessed as relevant. Conclusions Oxidized R-limonene is a common fragrance allergen, and limonene was frequently found in the labelling on the patients' products, and assessed as relevant for the patients' dermatitis. A large number of domestic and occupational sources for contact with R-limonene were identified. [ABSTRACT FROM AUTHOR]
- Subjects :
- LIMONENE
OXIDATION
ALLERGIES
CONTACT dermatitis
SKIN inflammation
Subjects
Details
- Language :
- English
- ISSN :
- 01051873
- Volume :
- 71
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Contact Dermatitis (01051873)
- Publication Type :
- Academic Journal
- Accession number :
- 99045426
- Full Text :
- https://doi.org/10.1111/cod.12285