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Decreased serum CA19-9 is associated with improvement of insulin resistance and metabolic control in patients with obesity and type 2 diabetes after Roux-en-Y gastric bypass.
- Source :
- Journal of Diabetes Investigation; Nov2014, Vol. 5 Issue 6, p694-700, 7p
- Publication Year :
- 2014
-
Abstract
- Aims/Introduction Patients with type 2 diabetes are known to show elevated serum levels of carbohydrate antigen 19-9 ( CA19-9). The aim of the present study was to investigate the possible relationships of CA19-9 with metabolic control, insulin resistance ( IR), and pancreatic β-cell function in patients with obesity and type 2 diabetes who underwent Roux-En-Y gastric bypass ( RYGB). Materials and Methods The present study included 81 healthy volunteers, and 33 patients diagnosed with obesity and type 2 diabetes who underwent RYGB. Anthropometry, serum levels of CA19-9, glucose and lipid metabolic profiles, and serum insulin levels were determined at baseline and at 12 weeks after RYGB. Results Changes in CA19-9 were significantly and positively correlated with changes in fasting plasma glucose ( r = 0.552, P = 0.001), 2-h post-challenge plasma glucose levels ( r = 0.623, P = 0.000), glycated hemoglobin levels ( r = 0.819, P = 0.000), glycated albumin levels ( r = 0.711, P = 0.000), total cholesterol ( r = 0.449, P = 0.009) and the Homeostasis Model of Assessment- IR index ( r = 0.407, P = 0.019). Furthermore, a multiple stepwise regression analysis showed that the changes in serum levels of CA19-9 were independently and significantly associated with changes in glycated hemoglobin (β = 0.598, P = 0.000), fasting plasma glucose (β = 0.309, P = 0.000) and Homeostasis Model of Assessment- IR (β = 0.235, P = 0.010) after adjusting for confounding factors. Conclusions CA19-9 could be an effective indicator of IR, and glycemic and lipid metabolism in patients with obesity and type 2 diabetes after rapid metabolic control by RYGB. Additionally, CA19-9 might be a marker with which to evaluate the short-term effects of glycolipid toxicity on IR in these patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- TYPE 2 diabetes
BLOOD sugar
BIPHASIC insulin
HYPERINSULINISM
PANCREATIC secretions
Subjects
Details
- Language :
- English
- ISSN :
- 20401116
- Volume :
- 5
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Journal of Diabetes Investigation
- Publication Type :
- Academic Journal
- Accession number :
- 99045286
- Full Text :
- https://doi.org/10.1111/jdi.12200