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Astragalus membranaceus Injection combined with conventional treatment for viral myocarditis: A systematic review of randomized controlled trials.
- Source :
- Chinese Journal of Integrative Medicine; Oct2014, Vol. 20 Issue 10, p787-791, 5p
- Publication Year :
- 2014
-
Abstract
- Objective: To assess the efficacy and safety of Astragalus membranaceus Injection combined with conventional therapy in the treatment of viral myocarditis. Methods: Randomized controlled trials (RCTs) of A. membranaceus Injection combined with conventional treatment compared with conventional treatment alone were included. Study population characteristics and outcome results were extracted independently by two assessors. Meta-analysis was performed for data available. Results: Six RCTs, involving 639 participants, were included in this study. The methodological quality of the included trials was generally low, and there was high risk of publication bias in the included trials. The total effective rate of A. membranaceus Injection combined with conventional treatment was significantly higher than that of conventional treatment alone. Compared with conventional treatment, the cointervention treatment group showed significant recovery in myocardium enzyme levels and electrocardiography. Two RCTs reported there were no adverse effects from A. membranaceus Injection combined with conventional treatment. Conclusion: A. membranaceus Injection combined with conventional treatment appeared to be more efficacious compared with conventional treatment alone for treating viral myocarditis. However, this conclusion should be cautiously interpreted due to low methodological quality, small sample size, limited number of trials, and high risk of publication bias and other unidentified risks of bias. The safety of A. membranaceus Injection combined with conventional treatment remains uncertain. [ABSTRACT FROM AUTHOR]
- Subjects :
- VIRUS disease drug therapy
ASTRAGALUS membranaceus
CHI-squared test
CONFIDENCE intervals
CREATINE kinase
ELECTROCARDIOGRAPHY
HERBAL medicine
MEDICAL databases
INFORMATION storage & retrieval systems
MEDICAL information storage & retrieval systems
INTRAVENOUS injections
LACTATE dehydrogenase
MEDICINE
CHINESE medicine
MEDLINE
CARDIOMYOPATHIES
ONLINE information services
HEALTH outcome assessment
RESEARCH funding
SYSTEMATIC reviews
INTEGRATIVE medicine
RANDOMIZED controlled trials
TREATMENT effectiveness
PUBLICATION bias
ODDS ratio
DRUG administration
DRUG dosage
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 16720415
- Volume :
- 20
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Chinese Journal of Integrative Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 98898761
- Full Text :
- https://doi.org/10.1007/s11655-014-1825-3