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Low expression of sodium iodide symporter expression in aggressive variants of papillary thyroid carcinoma.

Authors :
Wei, Songfeng
Gao, Ming
Zhao, Cui
Pan, Yi
Li, Haixin
Li, Jian
Li, Xiaolong
Source :
International Journal of Clinical Oncology; Oct2014, Vol. 19 Issue 5, p800-804, 5p
Publication Year :
2014

Abstract

Background: A decreased radioiodine uptake is associated with high recurrence rate and reduced survival in papillary thyroid carcinoma (PTC). Sodium iodide symporter (NIS) expression status in aggressive PTC variants is unknown. Methods: NIS expression in conventional PTC and aggressive PTC variants such as tall cell variant (TCV) and diffuse sclerosing variant (DSPTC) was investigated using immunohistochemical detection. Results: Patients having TCV and DSPTC were significantly more likely to have extrathyroidal extension and lymph nodes metastases ( P < 0.05). Positive NIS staining was identified in 228 of 312 (73.1 %) patients with conventional PTC, 9 of 28 (32.1 %) patients with TCV and 12 of 30 (40.0 %) patients with DSPTC. NIS expression distinguished conventional PTC from TCV and DSPTC significantly ( P < 0.01). Conclusion: Due to their low NIS expression, TCV and DSPTC need higher cumulative doses of radioactive iodine therapy to improve their prognosis. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13419625
Volume :
19
Issue :
5
Database :
Complementary Index
Journal :
International Journal of Clinical Oncology
Publication Type :
Academic Journal
Accession number :
98883011
Full Text :
https://doi.org/10.1007/s10147-013-0620-z