Back to Search
Start Over
A systematic review and Bayesian network meta-analysis of randomized clinical trials on non-surgical treatments for peri-implantitis.
- Source :
- Journal of Clinical Periodontology; Oct2014, Vol. 41 Issue 10, p1015-1025, 11p, 5 Charts, 3 Graphs
- Publication Year :
- 2014
-
Abstract
- Background/Aim It remains unclear which type of non-surgical treatment is most appropriate as first-line intervention against peri-implantitis. This systematic review and Bayesian network meta-analysis aimed to compare the clinical effect of various non-surgical peri-implantitis therapies. Methods The PubMed, SCOPUS, CINAHL, DARE and Web of Knowledge databases were searched in duplicate for randomized controlled trials ( RCTs) up to and including 01 January 2014. Additional relevant literature was identified using handsearching of reference lists within published systematic reviews, and screenings of OpenGrey, ClinicalTrials.gov and Controlled-Trials.com. Probing pocket depth ( PPD) was the outcome measure assessed. Multilevel mixed modelling was used to perform the network meta-analysis, and Markov Chain Monte Carlo simulation to obtain random effects. Results Eleven studies were included in the network meta-analysis. Debridement in conjunction with antibiotics achieved the greatest additional PPD reduction in comparison to debridement only (0.490 mm; 95% credible interval: −0.647;1.252). The highest probabilities of being the most effective interventions were achieved by Vector system ( p = 20.60%), debridement plus periochip ( p = 20.00%) and photodynamic therapy ( p = 18.90%). Conclusion The differences between various non-surgical treatments were relatively small with large credible intervals. On the basis of currently available RCTs, there is insufficient evidence to support that any particular non-surgical treatment for peri-implantitis showed better performance than debridement alone. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03036979
- Volume :
- 41
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Journal of Clinical Periodontology
- Publication Type :
- Academic Journal
- Accession number :
- 98403644
- Full Text :
- https://doi.org/10.1111/jcpe.12292