Expressions of uPA and PAI-1 in Colorectal Carcinoma and Their Correlations with Prognosis.

Objective To investigate the expressions of uPA and PAI-1 in colorectal carcinoma and discuss their correlations with tumor invasion and metastasis. Methods The expressions of uPA and PAI-1 in 29 cases of normal colorectal mucosa, 28 cases of colorectal adenoma, 51 cases of colorectal adenocarcinoma with no regional lymph node metastasis, and 50 cases of colorectal adenocarcinoma with regional lymph node metastasis were measured by immunohistochemical SP method. Results(1) The expressions of uPA and PAI-1 proteins were gradually increased during the development process of colorectal carcinoma, with significantly differences (P < 0.05). There were negative correlations betweens the expressions of uPA and PAI-1 proteins and regional lymph node metastasis (P <0.05, rs' =-0.7408 and P < 0.05, rs' =-0.7807). There was significantly difference in differentiation of colorectal adenocarcinoma (P < 0.05), while no significantly difference in the depth of invasion of the colorectal adenocarcinoma. (2) There was positive correlation relationship between the expressions of uPA and PAI-1 proteins in the colorectal adenocarcinoma (P < 0.05, rs' =0.2043). (3) According to the regression analysis results using the Cox proportional hazards model, the expression levels of the uPA protein, PAI-1 protein and the age of patients were the influencing factors for the postoperative survival of patients with colorectal cancer. Conclusion Both uPA and PAI-1 proteins play a role during the development of colorectal carcinoma, and are influence factors in the prognosis of colorectal cancer. [ABSTRACT FROM AUTHOR]