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Amide Alkaloids from Scopolia tangutica.
- Source :
- Planta Medica; 2014, Vol. 80 Issue 13, p1124-1130, 7p
- Publication Year :
- 2014
-
Abstract
- Four new hydroxycinnamic acid amides, scotanamines A-D (1-4), and seven known alkaloids, including N¹, N<superscript>10</superscript>-di-dihydrocaffeoylspermidine (5), scopolamine (6), anisodamine (7), hyoscyamine (8), anisodine (9), caffeoylputrescine (10), and N¹-caffeoyl-N³-dihydrocaffeoylspermidine (11), were obtained from the roots of Scopolia tangutica. The present study represents the first recognition of hydroxycinnamic acid amides containing putrescine or spermidine in S. tangutica. Compound 1, in particular, contains a moiety resulting from the condensation of nortropinone and putrescine. Compound 2 exhibited moderate agonist activity at the µ-opioid receptor (EC<subscript>50</subscript> = 7.3 µM). Compound 2 was tested in vivo and induced analgesia analgesia in mice. The analgesic effect was recorded using the tail-flick assay and was reversed by naloxone. [ABSTRACT FROM AUTHOR]
- Subjects :
- MEDICINAL plants
ALKALOIDS
ALTERNATIVE medicine
AMIDES
ANALGESICS
ANIMAL experimentation
BIOPHYSICS
CELL receptors
ANALYTICAL chemistry
PHYSICAL & theoretical chemistry
HIGH performance liquid chromatography
RESEARCH methodology
MICE
NARCOTICS
NUCLEAR magnetic resonance spectroscopy
RESEARCH funding
PLANT roots
PLANT extracts
BLIND experiment
DESCRIPTIVE statistics
PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 00320943
- Volume :
- 80
- Issue :
- 13
- Database :
- Complementary Index
- Journal :
- Planta Medica
- Publication Type :
- Periodical
- Accession number :
- 98042777
- Full Text :
- https://doi.org/10.1055/s-0034-1382961