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B-type (brain) natriuretic peptide and pruritus in hemodialysis patients.

Authors :
Yoshio Shimizu
Ayano Sonoda
Chieko Nogi
Yoko Ogushi
Reo Kanda
Saori Yamaguchi
Nao Nohara
Tatsuya Aoki
Kaori Yamada
Junichiro Nakata
Hiroaki Io
Atsushi Kurusu
Chieko Hamada
Satoshi Horikoshi
Yasuhiko Tomino
Source :
International Journal of Nephrology & Renovascular Disease; 2014, Vol. 7, p329-335, 7p
Publication Year :
2014

Abstract

Introduction and objective: While pruritus is a common complication in hemodialysis patients, the pathophysiological mechanisms remain obscure. Recently, B-type (brain) natriuretic peptide (BNP) has been defined as an itch-selective neuropeptide in pruriceptive neurons in mice, and higher serum levels of BNP are frequently observed in hemodialysis patients. The objective of the present study was to evaluate the role of serum BNP in pruritus in patients undergoing hemodialysis. Patients and methods: The current cross-sectional study was performed on 43 patients undergoing maintenance hemodialysis. A visual analog scale (VAS) measuring the general severity of pruritus (values from 0 to 10, with higher values indicating more severe pruritus) in daytime and at night was self-reported by patients. Each patient's background and laboratory tests, including serum BNP in the post-hemodialysis period, were collected. The correlation between VAS and clinical parameters was evaluated. Results: Both daytime and nighttime VAS scores in diabetic patients were significantly less than those in nondiabetic patients. Multiple regression analysis revealed that pruritus in daytime was worsened by serum BNP (β=2.0, t=2.4, P=0.03), calcium (β=4.4, t=5.2, P,0.0001), and β<subscript>2</subscript>-microglobulin (β=2.0, t=3.0, P=0.007), while it was eased by age (β=-2.2, t=-3.2, P=0.0004). Nocturnal pruritus was severe in nondiabetic patients (β=1.7, t=3.8, P=0.0005) and weakened by the total iron binding capacity (β=-2.9, t=-3.1, P=0.004). Conclusion: It is suggested that a higher level of serum BNP increases the pruritus of hemodialysis patients in daytime and that diabetic patients are less sensitive to itch, especially at nighttime. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
11787058
Volume :
7
Database :
Complementary Index
Journal :
International Journal of Nephrology & Renovascular Disease
Publication Type :
Academic Journal
Accession number :
97923490
Full Text :
https://doi.org/10.2147/IJNRD.S65929