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Spatial and temporal clustering of isolated cleft lip with or without cleft palate in Poland.
- Source :
- International Journal of Environmental Health Research; Nov2014, Vol. 24 Issue 6, p567-579, 13p, 2 Charts, 1 Graph, 2 Maps
- Publication Year :
- 2014
-
Abstract
- Background: Geographic variation in the prevalence of isolated cleft lip with or without cleft palate may be due to exogenous environmental factors or genetic variation. In this study, we aim to evaluate the prevalence of isolated cleft lip with or without cleft palate in Polish urban and rural environments in order to identify geographic areas with high prevalence (defect clusters). Methods: We use all cases of congenital malformations reported to the Polish Registry of Congenital Malformations in the years 1998–2008 from the total population of 2,362,502 births. Results: We detect a strong signal of increased prevalence of isolated cleft lip with or without cleft palate in a single region of Poland, the Dolnośląskie voivodeship. Furthermore, we demonstrate a statistically significant prevalence differences between the urban and rural areas within this region. Through our comprehensive spatiotemporal analysis, we precisely define the cluster of the highest risk that comprises the eastern part of this voivodeship. [ABSTRACT FROM AUTHOR]
- Subjects :
- CLEFT lip -- Risk factors
CHI-squared test
CLEFT palate
CLUSTER analysis (Statistics)
CONFIDENCE intervals
ENVIRONMENTAL health
INDUSTRIAL wastes
FISHER exact test
POPULATION geography
STATISTICAL sampling
STATISTICS
T-test (Statistics)
TIME
DATA analysis
DATA analysis software
DESCRIPTIVE statistics
ODDS ratio
MANN Whitney U Test
Subjects
Details
- Language :
- English
- ISSN :
- 09603123
- Volume :
- 24
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- International Journal of Environmental Health Research
- Publication Type :
- Academic Journal
- Accession number :
- 97902025
- Full Text :
- https://doi.org/10.1080/09603123.2014.883593