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Congenital heart defects and maternal fever: systematic review and meta-analysis.
- Source :
- Journal of Perinatology; Sep2014, Vol. 34 Issue 9, p677-682, 6p, 1 Diagram, 6 Charts
- Publication Year :
- 2014
-
Abstract
- OBJECTIVE:To systematically review and meta-analyze the relation between maternal fever in the first trimester and congenital heart defect (CHD) in offspring.STUDY DESIGN:We searched PubMed (1977-2012), Embase (1974-2012) and the Cochrane Library (2012) databases to identify relevant articles. Random effects model were performed, with the conduction of subgroup analysis.RESULT:Meta-analysis yielded a pooled odds ratio of 1.53 (95% confidence interval=1.36 to 1.73) for the magnitude of the relation between maternal fever in the first trimester and CHD in offspring. As to subgroup analysis, it is associated with ventricular septal defects (VSDs) and right obstructive defects.CONCLUSION:Our analysis suggests that maternal fever in the first trimester is the risk factor of congenital heart diseases in offspring. Through the subgroup analysis, we find that exposure to maternal fever is the risk factor of VSD and right obstructive defects. [ABSTRACT FROM AUTHOR]
- Subjects :
- HEART ventricle diseases
ANALYSIS of variance
CHI-squared test
CONFIDENCE intervals
CONGENITAL heart disease
FEVER
INFORMATION storage & retrieval systems
MEDICAL databases
MEDICAL information storage & retrieval systems
MATERNAL health services
MEDLINE
META-analysis
ONLINE information services
FIRST trimester of pregnancy
RESEARCH funding
SYSTEMATIC reviews
DATA analysis software
ODDS ratio
Subjects
Details
- Language :
- English
- ISSN :
- 07438346
- Volume :
- 34
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Journal of Perinatology
- Publication Type :
- Academic Journal
- Accession number :
- 97828211
- Full Text :
- https://doi.org/10.1038/jp.2014.76