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Japan Clinical Oncology Group (JCOG) prognostic index and characterization of long-term survivors of aggressive adult T-cell leukaemia-lymphoma (JCOG0902A).
- Source :
- British Journal of Haematology; Sep2014, Vol. 166 Issue 5, p739-748, 10p, 2 Diagrams, 2 Charts, 3 Graphs
- Publication Year :
- 2014
-
Abstract
- This study evaluated the clinical features of 276 patients with aggressive adult T-cell leukaemia-lymphoma (ATL) in 3 Japan Clinical Oncology Group (JCOG) trials. We assessed the long-term survivors who survived >5 years and constructed a prognostic index (PI), named the JCOG-PI, based on covariates obtained by Cox regression analysis. The median survival time (MST) of the entire cohort was 11 months. In 37 patients who survived >5 years, no disease-related deaths in 10 patients with lymphoma-type were observed in contrast to the 10 ATL-related deaths in other types. In multivariate analysis of 193 patients, the JCOG-PI based on corrected calcium levels and performance status identified moderate and high risk groups with an MST of 14 and 8 months respectively (hazard ratio, 1·926). The JCOG-PI was reproducible in an external validation. Patients with lymphoma-type who survived >5 years might have been cured. The JCOG-PI is valuable for identifying patients with extremely poor prognosis and will be useful for the design of future trials combining new drugs or investigational treatment strategies. [ABSTRACT FROM AUTHOR]
- Subjects :
- LEUKEMIA
LYMPHOMAS
T cells
REGRESSION analysis
MULTIVARIATE analysis
Subjects
Details
- Language :
- English
- ISSN :
- 00071048
- Volume :
- 166
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- British Journal of Haematology
- Publication Type :
- Academic Journal
- Accession number :
- 97460975
- Full Text :
- https://doi.org/10.1111/bjh.12962