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Adaptation of Candida albicans to growth on sorbose via monosomy of chromosome 5 accompanied by duplication of another chromosome carrying a gene responsible for sorbose utilization.
- Source :
- FEMS Yeast Research; Aug2014, Vol. 14 Issue 5, p708-713, 6p
- Publication Year :
- 2014
-
Abstract
- Candida albicans, a fungus that normally inhabits the digestive tract and other mucosal surfaces, can become a pathogen in immunocompromised individuals, causing severe or even fatal infection. Mechanisms by which C. albicans can evade commonly used antifungal agents are not fully understood. We are studying a model system involving growth of C. albicans on toxic sugar sorbose, which represses synthesis of cell wall glucan and, as a result, kills fungi in a manner similar to drugs from the echinocandins class. Adaptation to sorbose occurs predominantly due to reversible loss of one homolog of chromosome 5 (Ch5), which results in upregulation of the metabolic gene SOU1 ( SOrbose Utilization) on Ch4. Here, we show that growth on sorbose due to Ch5 monosomy can involve a facultative trisomy of a hybrid Ch4/7 that serves to increase copy number of the SOU1 gene. This shows that control of expression of SOU1 can involve multiple mechanisms; in this case, negative regulation and increase in gene copy number operating simultaneously in cell. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15671356
- Volume :
- 14
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- FEMS Yeast Research
- Publication Type :
- Academic Journal
- Accession number :
- 97370530
- Full Text :
- https://doi.org/10.1111/1567-1364.12155