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Effect of Multivitamin Supplementation on the Neurodevelopment of HIV-Exposed Tanzanian Infants: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
- Source :
- Journal of Tropical Pediatrics; Aug2014, Vol. 60 Issue 4, p279-286, 8p
- Publication Year :
- 2014
-
Abstract
- Background: Micronutrient deficiencies and in utero exposure to HIV may impair infant neurodevelopment.Objective: To evaluate the effect of daily multivitamin supplementation on the cognitive, language and motor development of HIV-exposed Tanzanian infants.Methods: A total of 2387 infants were randomized to receive daily oral supplementation of multivitamins (B-complex, C and E) or placebo from age 6 weeks for 24 months. The cognitive, language and motor scales of the Bayley Scales of Infant and Toddler Development, third edition, were administered to a subset of 206 infants at age 15 months.Results: Multivitamin supplementation did not improve measures of cognitive development, expressive or receptive language or gross motor capabilities. There was a trend toward improved fine motor skills among infants randomized to the multivitamin group (difference in mean score = 0.38; 95% CI = −0.01, 0.78, p = 0.06).Conclusion: Daily provision of multivitamins to HIV-exposed infants does not substantially improve developmental outcomes at age 15 months. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01426338
- Volume :
- 60
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Journal of Tropical Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 97328298
- Full Text :
- https://doi.org/10.1093/tropej/fmu011