Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites.

Authors :: Sleebs, Brad E.
Lopaticki, Sash
Marapana, Danushka S.
O'Neill, Matthew T.
Rajasekaran, Pravin
Gazdik, Michelle
Günther, Svenja
Whitehead, Lachlan W.
Lowes, Kym N.
Barfod, Lea
Hviid, Lars
Shaw, Philip J.
Hodder, Anthony N.
Smith, Brian J.
Cowman, Alan F.
Boddey, Justin A.
Source :: PLoS Biology; Jul2014, Vol. 12 Issue 7, p1-16, 16p
Publication Year :: 2014
Abstract: : A small molecule inhibitor of the malarial protease Plasmepsin V impairs protein export and cellular remodeling, reducing parasite survival in human erythrocytes. [ABSTRACT FROM AUTHOR]

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