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Possible pro-carcinogenic association of endotoxin on lung cancer among Shanghai women textile workers.

Authors :
Checkoway, H
Lundin, J I
Costello, S
Ray, R
Li, W
Eisen, E A
Astrakianakis, G
Seixas, N
Applebaum, K
Gao, D L
Thomas, D B
Source :
British Journal of Cancer; 7/29/2014, Vol. 111 Issue 3, p603-607, 5p, 3 Charts
Publication Year :
2014

Abstract

Background:Endotoxin (lipopolysaccharide) is a widespread contaminant in many environmental settings. Since the 1970s, there has been generally consistent evidence indicating reduced risks for lung cancer associated with occupational endotoxin exposure.Methods:We updated a case-cohort study nested within a cohort of 267 400 female textile workers in Shanghai, China. We compared exposure histories of 1456 incident lung cancers cases diagnosed during 1989-2006 with those of a reference subcohort of 3022 workers who were free of lung cancer at the end of follow-up. We applied Cox proportional hazards modelling to estimate exposure-response trends, adjusted for age and smoking, for cumulative exposures lagged by 0, 10, and 20 years, and separately for time windows of ⩽15 and >15 years since first exposure.Results:We observed no associations between cumulative exposure and lung cancer, irrespective of lag interval. In contrast, analyses by exposure time windows revealed modestly elevated, but not statistically significant relative risks (∼1.27) at the highest three exposure quintiles for exposures that occurred >15 years since first exposure.Conclusions:The findings do not support a protective effect of endotoxin, but are suggestive of possible lung cancer promotion with increasing time since first exposure. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00070920
Volume :
111
Issue :
3
Database :
Complementary Index
Journal :
British Journal of Cancer
Publication Type :
Academic Journal
Accession number :
97251997
Full Text :
https://doi.org/10.1038/bjc.2014.308