Genetic burden of common variants in progressive and bout-onset multiple sclerosis.

The article focuses on a study that estimate and compare the proportion of liability explained by common single nucleotide polymorphisms (SNPs) and the genetic burden of multiple sclerosis (MS)-associated SNPs in progressive onset (PrMS) and bout-onset (BOMS) cases. Study calculated a weighted genetic risk score (wGRS) based on the known MS-associated loci and found that common SNPs explain a greater proportion of phenotypic variance in BOMS.