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Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension.
- Source :
- Nature; 10/30/1997, Vol. 389 Issue 6654, p990, 5p, 10 Black and White Photographs, 1 Diagram, 1 Chart, 11 Graphs
- Publication Year :
- 1997
-
Abstract
- Presents research which showed that a pyridine derivative Y-27632 selectively inhibits smooth-muscle contraction by inhibiting Ca2+ sensitization. Abnormal smooth-muscle contractility; Regulation of smooth-muscle contraction; Role of small GTPase Rho and Rho-associated kinase; Y-27632 target a Rho-associated protein kinase, p160ROCK7; Role of p160ROCK-mediated Ca2+ sensitization in pathophysiology of hypertension. INSET: Methods..
Details
- Language :
- English
- ISSN :
- 00280836
- Volume :
- 389
- Issue :
- 6654
- Database :
- Complementary Index
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 9711120226
- Full Text :
- https://doi.org/10.1038/40187