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The Relationship Between Angiotensinogen Gene Polymorphisms and Essential Hypertension in a Northern Han Chinese Population.
- Source :
- Angiology; Aug2014, Vol. 65 Issue 7, p614-619, 6p
- Publication Year :
- 2014
-
Abstract
- Gene polymorphisms of the renin–angiotensin system are involved in the pathophysiology of hypertension. We genotyped 4 polymorphisms of angiotensinogen (AGT) gene A-20C (rs5050), A-6G (rs5051), C3889T (rs4762), and C4072T (rs699) by polymerase chain reaction-restriction fragment length polymorphism in 652 patients and 780 controls to examine the association of AGT and hypertension in a Northern Han Chinese population. There were significant differences in the distribution of genotypes and allele frequencies at C4072T between the patients and the controls (both P < .01); patients with CC genotype had a higher risk of hypertension (odds ratio = 1.7, 95% confidence interval 1.4–2.1). The distribution of genotypes at A-6G was significantly different between patients and controls (P < .05). No other significant differences in genotypes or frequencies were observed. No association was observed between the haplotypes of AGT and hypertension. The AGT-6A and 4072C alleles are associated with susceptibility to hypertension in this population. [ABSTRACT FROM PUBLISHER]
- Subjects :
- HYPERTENSION genetics
ALLELES
ANGIOTENSINS
BLOOD pressure measurement
CHI-squared test
CONFIDENCE intervals
GENES
GENETIC polymorphisms
HYPERTENSION
POLYMERASE chain reaction
RESEARCH funding
T-test (Statistics)
RENIN-angiotensin system
CASE-control method
DATA analysis software
DESCRIPTIVE statistics
ODDS ratio
Subjects
Details
- Language :
- English
- ISSN :
- 00033197
- Volume :
- 65
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Angiology
- Publication Type :
- Academic Journal
- Accession number :
- 96920936
- Full Text :
- https://doi.org/10.1177/0003319713491309