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Single-Cell-Precision Microplasma-Induced Cancer Cell Apoptosis.
- Source :
- PLoS ONE; Jun2014, Vol. 9 Issue 6, p1-10, 10p
- Publication Year :
- 2014
-
Abstract
- The issue of single-cell control has recently attracted enormous interest. However, in spite of the presently achievable intracellular-level physiological probing through bio-photonics, nano-probe-based, and some other techniques, the issue of inducing selective, single-cell-precision apoptosis, without affecting neighbouring cells remains essentially open. Here we resolve this issue and report on the effective single-cell-precision cancer cell treatment using the reactive chemistry of the localized corona-type plasma discharge around a needle-like electrode with the spot size ∼1 µm. When the electrode is positioned with the micrometer precision against a selected cell, a focused and highly-localized micro-plasma discharge induces apoptosis in the selected individual HepG2 and HeLa cancer cells only, without affecting any surrounding cells, even in small cell clusters. This is confirmed by the real-time monitoring of the morphological and structural changes at the cellular and cell nucleus levels after the plasma exposure. [ABSTRACT FROM AUTHOR]
- Subjects :
- MICROPLASMAS
CANCER cells
APOPTOSIS
PHOTONICS
CELL nuclei
PLASMA flow
CANCER treatment
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 9
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- PLoS ONE
- Publication Type :
- Academic Journal
- Accession number :
- 96861262
- Full Text :
- https://doi.org/10.1371/journal.pone.0101299