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New Coumarins and Anti-Inflammatory Constituents from the Fruits of Cnidium monnieri.
- Source :
- International Journal of Molecular Sciences; Jun2014, Vol. 15 Issue 6, p9566-S12, 25p, 4 Diagrams, 1 Chart
- Publication Year :
- 2014
-
Abstract
- The fruit of Cnidium monnieri is commercially used as healthcare products for the improvement of impotence and skin diseases. Three new coumarins, 3'-O-methylmurraol (1), rel-(1'S,2'S)-1'-O-methylphlojodicarpin (2), and (1'S,2'S)-1'-O-methylvaginol (3), have been isolated from the fruits of C. monnieri, together with 14 known compounds (4-17). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1, 4-12, and 14-17 exhibited inhibition (IC50 = 7.31 µg/mL) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-LOPEN leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 7, 9-11, 15, and 17 inhibited fMLP/CB-induced elastase release with IC50 values =7.83 µg/mL. This investigation reveals that bioactive isolates (especially 6, 7, 14, and 17) could be further developed as potential candidates for the treatment or prevention of various inflammatory diseases. [ABSTRACT FROM AUTHOR]
- Subjects :
- UMBELLIFERAE
COUMARINS
IMPOTENCE
SKIN diseases
SUPEROXIDES
INFLAMMATION
PHENYLALANINE
Subjects
Details
- Language :
- English
- ISSN :
- 16616596
- Volume :
- 15
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- International Journal of Molecular Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 96841970
- Full Text :
- https://doi.org/10.3390/ijms15069566