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A Novel Domino Synthesis of Quinazolinediones by Palladium-Catalyzed Double Carbonylation.
- Source :
- Chemistry - A European Journal; Jul2014, Vol. 20 Issue 28, p8541-8544, 4p
- Publication Year :
- 2014
-
Abstract
- Combining commercially available bromoanilines and bromobenzonitriles in a novel double carbonylation process allows for a straightforward synthesis of isoindolo[1,2-b]quinazoline-10,12-diones. At least five different CC and/or CN bonds are selectively formed in this 3-component reaction, which likely proceeds through sequential carbonylation-cyclization-isomerisation-carbonylation steps. Notably, two molecules of CO are inserted in this highly efficient palladium-catalyzed process. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09476539
- Volume :
- 20
- Issue :
- 28
- Database :
- Complementary Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Academic Journal
- Accession number :
- 96838661
- Full Text :
- https://doi.org/10.1002/chem.201403417