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Post-partum weight loss and glucose metabolism in women with gestational diabetes: the DEBI Study.
- Source :
- Diabetic Medicine; Jul2014, Vol. 31 Issue 7, p862-867, 6p
- Publication Year :
- 2014
-
Abstract
- Aims Women with gestational diabetes are at high risk for developing diabetes; post-partum weight loss may reduce the risk of diabetes. We evaluated the association of post-partum weight change with changes in glucose, insulin and homeostasis model assessment of insulin resistance in a subsample ( n = 72) of participants from Diet Exercise and Breastfeeding Intervention ( DEBI), a randomized pilot trial of lifestyle intervention for women with gestational diabetes. Methods Glucose and insulin were measured fasting and 2 h after an oral glucose tolerance test at 6 weeks and 12 months post-partum. Women were categorized by weight change (lost > 2 kg vs. maintained/gained) between 6 weeks and 12 months post-partum. Results Compared with women who maintained or gained weight, women who lost > 2 kg experienced significantly lower increases in fasting glucose [age-adjusted means: 0.1 mmol/l (95% CI -0.03 to 0.3) vs. 0.4 mmol/l (95% CI 0.3-0.6); P < 0.01] and 2-h insulin [10.0 pmol/l (95% CI -56.9 to 76.9) vs. 181.2 pmol/l (95% CI 108.3-506.9); P < 0.01] and a significant reduction in 2-h glucose [-0.9 mmol/l (95% CI -1.4 to -0.3) vs. 0.3 mmol/l (95% CI -0.3 to 0.9); P < 0.01]. In multiple linear regression models adjusted for age, Hispanic ethnicity, medication use, meeting the Institute of Medicine's recommendations for gestational weight gain, breastfeeding and randomized group, a 1-kg increase in weight was significantly associated with increases in fasting and 2-h glucose ( P < 0.05), but was not associated with insulin or homeostasis model assessment of insulin resistance. Conclusions In women with gestational diabetes, modest post-partum weight loss may be associated with improvements in glucose metabolism. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 07423071
- Volume :
- 31
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Diabetic Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 96576251
- Full Text :
- https://doi.org/10.1111/dme.12425