Toll like receptor 2 knock-out attenuates carbon tetrachloride (CCl4)-induced liver fibrosis by downregulating MAPK and NF-κB signaling pathways.

Highlights: [•] CCl₄-induced elevation of serum ALP and TBIL was reduced in TLR2^−/− mice. [•] CCl₄-induced liver collagen deposition was attenuated in TLR2^−/− mice. [•] CCl₄-induced inflammatory response was ameliorated in TLR2^−/− mice. [•] CCl₄-induced activation of MAPK and NF-κB signaling pathways was attenuated in TLR2^−/− mice. [Copyright &y& Elsevier]