Gene polymorhisms of water and glycerol channels aquaporin 7 and 9 in obese and/or diabetic patients.

The alterations that may occur during glycerol transport between adipose tissue and liver can play an important role in the development of diabetes or obesity (1,2). In this study, polymorphisms of aquaporin 7 that provides glycerol release from adipose tissue and aquaporin 9 that provides glycerol entry into liver were investigated. After ethical approval, three groups were created by participants who signed the informed consent form. Group 1, the individuals with normal weight and no diabetes (n=49; M/W, 18/31; mean age, 36±10 year), Group 2, the individuals with obesity and no diabetes (n=60; M/W, 29/31; mean age, 47±10 year) and Group 3, the individuals with type 2 diabetes mellitus and obesity (n=89, M/W venous blood samples. Polymorphisms of aquaporin 7 in 2 locations (V59L "rs: 4008659" and A953G "rs:2989924") and aquaporin 9 in 2 locations (C43T "rs:77284866" and T279A" rs:1867380") were studied. The rate of aquaporin 7 and aquaporin 9 polymorphisms were similar among the study groups. Statistical analysis showed that the levels of insulin and glycerol were significantly different (The mean insulin values 7.21±0.94, 13.71±2.20 and 18.21±2.32; the mean glycerol values 0.68±0.04, 0.79±0.05 and 0.97±0.05 in Group 1, 2 and 3, respectively, p<0.001 for both). Considering the polymorphisms of A953G and T276A, plasma glycerol and insulin levels were similar in subjects with different genotypes. These results suggested that polymorphisms of aquaporin 7 and aquaporin 9 were not associated with presence of obesity and/or diabetes. [ABSTRACT FROM AUTHOR]