MET Mutations in Non-small Cell Lung Cancer: Four Case Reports of Mutations at or Near the Splice Junction for Exon 14.

The article offers information on a research on the mutations at or near the splice junction for exon 14 in non-small cell lung cancer (NSCLC). Topics discussed include activation of MET receptor tyrosine kinase (RTK) and its ligand, hepatocyte growth factor (HGF) in cancers, treatment implications for the lung cancers, and clinical trials of the patients with NSCLC. Also mentioned are examining the effect of erlotinib drug and DNA sequencing analysis and staining analysis of the cancer.