HDL cholesterol and the risk of depression over 5 years.

The article discusses a study which examines the association between the low concentration of plasma high-density lipoprotein (HDL) cholesterol with increased risk of depression over five years, independent of cardiovascular diseases, diabetes and history of past depression. It showed that the reverse dose effect of HDL cholesterol risk of depression was prominent in men with history of past depression. It indicated the significant role of lipid metabolism in maintaining brain health.