Back to Search
Start Over
Mammary Analogue Secretory Carcinoma of the Parotid Gland as a Secondary Malignancy in a Childhood Survivor of Atypical Teratoid Rhabdoid Tumor.
- Source :
- Head & Neck Pathology; Jun2014, Vol. 8 Issue 2, p194-197, 4p
- Publication Year :
- 2014
-
Abstract
- We report the first case of mammary analogue secretory carcinoma (MASC) arising as a secondary malignancy in a 14 years old child with a history of atypical teratoid rhabdoid tumor (ATRT). Although MASC and ATRT are both rare malignancies, they do not share the same genetic and molecular profiles. MASC is a salivary malignancy characterized by a t(12;15)(p13;q25) translocation, resulting in an ETV6-NTRK3 fusion product encoding for a tyrosine kinase. ATRT is a highly malignant pediatric tumor characterized by a chromosome 22 mutation in the hSNF5/INI1 gene, encoding for a chromatin remodeling protein. Additionally, although mucoepidermoid carcinoma has been described as a secondary malignancy post-therapy for head and neck tumors, MASC has only been reported as a primary malignancy. Our patient was treated with a complete resection of his left sided ATRT at age 3 followed postoperatively with chemoradiotherapy. At age 14 he underwent a parotidectomy for his 1 year history of a left sided preauricular mass and was subsequently diagnosed with MASC. We not only report a case of two rare malignancies in one patient, but also the first case of MASC arising as a secondary malignancy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1936055X
- Volume :
- 8
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Head & Neck Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 96032321
- Full Text :
- https://doi.org/10.1007/s12105-013-0481-9