Back to Search
Start Over
Dexamethasone reduces ATDC5 chondrocyte cell viability by inducing autophagy.
- Source :
- Molecular Medicine Reports; 2014, Vol. 9 Issue 3, p923-927, 5p
- Publication Year :
- 2014
-
Abstract
- Prolonged use of glucocorticoids (GCs) for the treatment of chronic inflammatory and autoimmune diseases commonly exerts various side-effects, including impairment of skeletal development. However, the effect of GCs on chondrocytes, which play a key role in skeletal development, has been rarely reported. In the present study, autophagy was induced in the ATDC5 chondrocyte cell line following treatment with dexamethasone (Dex) at doses of 1-100 μM, and that this effect can be inhibited by RU486, a GC antagonist. Autophagy induced by the highest Dex dose (100 μM) was associated with a reduction in ATDC5 cell viability. We conclude that high doses of GC can reduce ATDC5 chondrocyte cell viability by inducing autophagy. [ABSTRACT FROM AUTHOR]
- Subjects :
- DEXAMETHASONE
CARTILAGE cells
AUTOIMMUNE diseases
IMMUNOLOGIC diseases
AUTOIMMUNITY
Subjects
Details
- Language :
- English
- ISSN :
- 17912997
- Volume :
- 9
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Molecular Medicine Reports
- Publication Type :
- Academic Journal
- Accession number :
- 95982315
- Full Text :
- https://doi.org/10.3892/mmr.2014.1915