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Well-Defined Four-Coordinate Iron(II) Complexes For Intramolecular Hydroamination of Primary Aliphatic Alkenylamines.
- Source :
- Angewandte Chemie International Edition; May2014, Vol. 53 Issue 19, p4930-4934, 5p
- Publication Year :
- 2014
-
Abstract
- Despite the growing interest in iron catalysis and hydroamination reactions, iron-catalyzed hydroamination of unprotected primary aliphatic amines and unactivated alkenes has not been reported to date. Herein, a novel well-defined four-coordinate β-diketiminatoiron(II) alkyl complex is shown to be an excellent precatalyst for the highly selective cyclohydroamination of primary aliphatic alkenylamines at mild temperatures (70-90 °C). Both empirical kinetic analyses and the reactivity of an isolated iron(II) amidoalkene dimer, [LFe(NHCH<subscript>2</subscript>CPh<subscript>2</subscript>CH<subscript>2</subscript>CHCH<subscript>2</subscript>)]<subscript>2</subscript> favor a stepwise σ-insertive mechanism that entails migratory insertion of the pendant alkene into an iron-amido bond associated with a rate-determining aminolysis step. [ABSTRACT FROM AUTHOR]
- Subjects :
- HYDROAMINATION
ALIPHATIC amines
TEMPERATURE
CATALYSIS
DYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 53
- Issue :
- 19
- Database :
- Complementary Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 95829565
- Full Text :
- https://doi.org/10.1002/anie.201402089