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Diffuse reflectance spectroscopy in Barrett's Esophagus: developing a large field-of-view screening method discriminating dysplasia from metaplasia.

Authors :
Douplik, Alexandre
Zanati, Simon
Saiko, Guennadi
Streutker, Catherine
Loshchenov, Maxim
Adler, Desmond
Cho, Sarah
Chen, Dean
Cirocco, Maria
Marcon, Norman
Fengler, John
Wilson, Brian C.
Source :
Journal of Biophotonics; May2014, Vol. 7 Issue 5, p304-311, 8p
Publication Year :
2014

Abstract

We evaluated diffuse reflectance spectroscopy implemented as a small field-of-view technique for discrimination of dysplasia from metaplasia in Barrett's esophagus as an adjuvant to autofluorescence endoscopy. Using linear discriminant analysis on 2579 spectra measured in 54 patients identified an optimum a 4-wavelength classifier (at 485, 513, 598 and 629 nm). Sensitivity and specificity for a test data set were 0.67 and 0.85, respectively. Spectroscopic results show that this technique could be implemented in wide-field imaging mode to improve the accuracy of existing endoscopy techniques for finding early pre-malignant lesions in Barrett's esophagus. Results show that the discrimination occurs likely due to redistribution of blood content in the tissue sensed by the optical probing with the wavelength-dependent sampling depth. (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1864063X
Volume :
7
Issue :
5
Database :
Complementary Index
Journal :
Journal of Biophotonics
Publication Type :
Academic Journal
Accession number :
95829497
Full Text :
https://doi.org/10.1002/jbio.201200114