THERAPEUTIC APPROACH IN PRADER-WILLI SYNDROME.

Prader-Willi syndrome (PWS) is a genetic disorder characterized by absence of the active genes on chromosome 15. Symptoms appear since intrauterine development with decreased fetal movements, low birth weight and persist after birth with hypotonia, feeding difficulties and failure to thrive in the neonatal period. From infancy until adulthood, patients have short stature, become severely obese, with an insatiable appetite and food-seeking behavior. They also have psychiatric disorders, behavioral problems and learning disabilities. Treatment of these patients is multidisciplinary and several drugs have been studied in order to control appetite and reduce the morbidity of obesity, including cardiovascular and metabolic side-effects. The following paper offers an insight in the difficult management of the co-morbidities of Prader-Willi syndrome. [ABSTRACT FROM AUTHOR]